Posted on December 6, 2021
Introduction To CD16 Antibodies
The natural killer (NK) cells are part of the immune system's innate component that plays a key role in the prevention of viral infections as well as defense against tumor cells in the host as well as involved in the rejection of transplanted tissue. You can know more about anti-CD16/FCGR3A antibody picoband online.
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Since knockout and transgenic primates aren't available We and other researchers have been experimenting with the use of monoclonal antibodies to deplete and target macaque monkeys of specific TB and T-lymphocyte subsets to determine the role of the particular elements that make up the acquired immune response in the management of several viral infections.
Therefore, we set out to design an analogous model that utilized antibodies to reduce NK cells from rhesus monkeys.
NK cells are a diverse lymphocyte population, which lacks an underlying immunophenotypic marker. Additionally, a wide range of differences is observed between the immunophenotypes of macaque and human NK cells, with the most notable being the absence of CD56 expression in macaque NK cells.
However, prior studies have revealed that CD16, also known as the Fc receptor FcgRIII that is present on 90 to 99% or more of lymphocytes in the rhesus that have NK-cell function,13 which suggests that this cell surface marker could be a valuable marker for NK cells.
Therefore, we investigated the possibility of making an anti-CD16 antibody specifically targeting and eliminating NK cells in rhesus monkeys.
In this study, we demonstrate our findings that anti-human CD16 antibody 3G8 has the capability of transiently eliminating up to 90 percent of NK cells present in the blood of rhesus macaques and decreasing NK-cell lytic activity the blood to close to the levels of.